＊The Food Safety Commission of Japan published the new guidelines for the risk assessment of flavoring substances on May 17,2016.
「Guidelines for the Assessment of Flavoring Substances in Foods on Health」
Along with the new guidelines, the MHLW issued an English translation of the Guidelines for the Designation of Flavoring Agents that describes that the details of dossier preparation, i.e. how to preparation the dossier, what kind of data is required(other than safety data), etc.
「Guidelines for the Designation of Flavoring Agents」
[cf.] "Food additives" website in MHLW
＊New synthetic flavoring agents in last nine years allowed to be used only when they are designated by the Minister of Health, Labour and Welfare as food additives. (2015.09.18)
| designated date | name |
| 2015/09/18 | 1-Methylnaphthalen |
| 2015/07/29 | Ammonium isovalerate |
| 2014/11/17 | 2,3-Diethylpyrazine |
| 2013/08/06 | 3-Ethylpyridine |
| 2012/12/28 | trans-2-Methyl-2-butenal |
| 2012/12/28 | Trimethylamine |
| 2012/12/28 | Mixture of 2-ethyl-6-methypyrazine and 2-ethyl-5-methylpyrazine |
| 2012/12/28 | (3-Amino-3-carboxypropyl)dimethylsulfonium chloride |
| 2012/11/02 | trans-2-Pentenal |
| 2011/12/27 | Isoquinoline |
| 2011/12/27 | Pyrrole |
| 2011/7/19 | Pyrazine |
| 2011/7/19 | 1-Penten-3-ol |
| 2011/7/19 | 3-Methyl-2-butenal |
| 2011/7/19 | 3-Methyl-2-butenol |
| 2011/6/28 | 2,3-Diethyl-5-methylpyrazine |
| 2011/6/28 | 2-(3-Phenylpropyl)pyridine |
| 2011/6/28 | 5-Methyl-6,7-dihydro-5H-cyclopentapyrazine |
| 2011/3/15 | 2,6-Dimethylpyridine |
| 2011/3/15 | 5-Ethyl-2-methylpyridine |
| 2010/12/13 | Piperidine |
| 2010/12/13 | Pyrrolidine |
| 2010/11/10 | Butylamine |
| 2010/11/10 | Phenethylamine |
| 2010/10/20 | 2-Ethyl-5-methylpyrazine |
| 2010/10/20 | Isopropylamine |
| 2010/5/28 | 2-Methylpyrazine |
| 2010/5/28 | 2-Ethylpyrazine |
| 2010/5/28 | Propionaldehyde |
| 2010/5/28 | 2-Methylbutyraldehyde |
| 2010/5/28 | 6-Methylquinoline |
| 2010/5/28 | 2-Pentanol |
| 2010/5/28 | 3-Methyl-2-butanol |
| 2010/5/28 | 5,6,7,8-Tetrahydroquinoxaline |
| 2009/6/4 | Isovaleraldehyde |
| 2009/6/4 | Valeraldehyde |
| 2009/6/4 | 2,3-Dimethylpyrazine |
| 2009/6/4 | 2,5-Dimethylpyrazine |
| 2009/6/4 | 2,6-Dimethylpyrazine |
| 2007/10/26 | Butanal |
| 2007/8/3 | Isobutyraldehyde |
| 2007/8/3 | 2-Methylbutyl alcohol |
| 2006/9/12 | Butanol |
| 2006/5/16 | Acetaldehyde |
| 2006/5/16 | 2-Ethyl-3-methylpyrazine |
| 2006/5/16 | 5-Methylquinoxaline |
| 2005/8/19 | 2,3,5-Trimethylpyrazine |
| 2005/8/19 | Amyl alcohol |
| 2005/8/19 | Isoamyl alcohol |
| 2005/4/28 | Isopropanol |
| 2005/2/24 | Propanol |
| 2004/12/24 | Isobutyl alcohol |
| 2004/12/24 | 2,3,5,6-Tetramethylpyrazine |
| 2004/12/24 | 2-Ethyl-3,(5or6)-dimethylpyrazine |